Do it because it sucks putting up Christmas decorations. It sucks putting up the tree, untangling all the lights, getting all that crap out of Florida Gators Hawaiian Shirt storage and tossing around with meaningless baubles like each placement is life-or-death perfectionist fun. And we want to get the most out of that effort. Depending on how many “helpers” I have, it can take one to four hours just putting up the tree. (It’s frealistic, over two metres tall, and has individual coded branches.) The more helpers, the longer it takes. And it’s hot where we live. By the end I’m peed off, drenched, covered in sweat, and I haven’t even done the lights yet. Which are tangled to f*&#. Then the kids pull out all the decorations and place them random patchy over the lower sections of the tree, despite encouragement to maybe spread them around (and make it look goodish). So I wait for them to go to school the next day and redo all the decorations. It’s basically a couple days work for all the Chrissy dex.
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Glioblastoma (GBM). GBM is the most Florida Gators Hawaiian Shirt and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.