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Glioblastoma (GBM). GBM is the most Official 311 On August 20, 2024 In Houston, TX Tour Poster Unisex T Shirt and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.
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At this point Mephistopheles returns and Beethoven informs the Official 311 On August 20, 2024 In Houston, TX Tour Poster Unisex T Shirt that he will not allow his music to be destroyed. Desperate to receive the Tenth Symphony, Mephistopheles makes another deal: if Beethoven will give over only the Tenth Symphony, then Mephistopheles will not take the composer’s soul. After an appearance by Mozart’s ghost, Beethoven refuses this offer as well. As a final tactic, Mephistopheles points out the window to a young orphan and describes the tortures that she will receive if Beethoven refuses to hand over his music. Heartbroken, Beethoven agrees to hand over his Tenth Symphony. After Twist’s prompting, a contract is drawn up by Fate stating the following.