Glioblastoma (GBM). GBM is the most Five Guys Ugly Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.
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In the typical Tim Burton fashion, there were many twisted versions of holiday traditions. Such as when Penguin blackmails Max using his stocking to hide the dirt he has on him. As Batman and Catwoman commenting on mistletoe which gives away their identities. It’s part of the Five Guys Ugly Sweater nicknamed Tim Burton Christmas Trilogy. With it being the first and Edward Scissorhands and Nightmare Before Christmas being the second and third.
No! It’s much too early for Five Guys Ugly Sweater . I want to enjoy this fall (although it seems that fall has decided not to visit us this year) and each holiday as it comes. One year, ages ago, I put up the Christmas tree on Thanksgiving weekend and by the time Christmas came around, all the decorations were dusty and I was sick of looking at it..lol. That was a good lesson. Christmas, for me, is sparkling snow, pine trees (not maples turning gold and red) and a very special time, especially if you have family (cherish them because some day they will be gone). It’s a time of selflessness and love and that “Christmas spirit” which is incredible which takes hold of you.